1. Welcome to Core & Main - Core & Main
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CASE STUDY: WATER METERING MEANS QUALITY OF LIFE IMPROVEMENTS LEARN MORE WATER & WASTEWATER SUPPLY SHOP NOW CASE STUDY: RED HILL RAPID RESPONSE BRINGS RELIEF LEARN MORE SAVING LIVES & PROTECTING PROPERTY We’ve got your back Learn More We are the team you can count on. Our vision is to foster a world where communities […]
2. Between Main Campus, HSC, and Ambler
Shuttle Services between Main Campus, HSC & Ambler. Main Campus bus stop is located at Broad and Polett Walk for all arrivals and departures.
Main Campus bus stop is located at Broad and Polett Walk for all arrivals and departures.
3. Paul's on Main Street Food and Spirits
Paul's is the best family restaurant in Rochester. Great breakfast, lunch or dinner options. Great service in a family friendly atmosphere. ”.
Family style restaurant
4. Front & Main | Comfort Food in Waterville, ME
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Waterville's most anticipated new restaurant, Front & Main aims to transform the local food scene with creative nourishing cuisine sourced lovingly from our own farms, fields, bays, and oceans. Located in Waterville, ME.
5. Anne Arundel Community College: Home
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AACC entrance sign, students with AACC mascot, women's soccer drill, AACC cafeteria, students laughing, students in a variety of classroom settings, students looking into telescope and a scan of AACC's campus.
6. University of Arizona Libraries
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The University of Arizona Libraries provides access to research materials, study spaces, and technology.
7. Joss & Main | The ultimate style edit for home
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Shop your signature style at Joss & Main. Part contemporary. Part classic. Our affordable mix works effortlessly in any home. Free shipping over $35.
8. The University of Akron : YOU BELONG HERE! : The University of ...
You belong here! Attend one of the top public universities in Ohio and the nation. Discover The University of Akron's programs, admissions, and student ...
You belong here! Attend one of the top public universities in Ohio and the nation. Discover The University of Akron’s programs, admissions, and student life.
9. The main characters | Anne Frank House
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During the Second World War, Anne Frank's family went into hiding in the Secret Annex with the Van Pels family and Fritz Pfeffer. Get to know them here.
10. Crystallographic and electrophilic fragment screening of the SARS ...
Oct 7, 2020 · ... and non-covalent fragments through a combined mass spectrometry and X-ray approach against the SARS-CoV-2 main protease, one of two cysteine ...
COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral drugs or vaccines were developed against the closely related coronavirus, SARS-CoV-1 or MERS-CoV, despite previous zoonotic outbreaks. To identify starting points for such therapeutics, we performed a large-scale screen of electrophile and non-covalent fragments through a combined mass spectrometry and X-ray approach against the SARS-CoV-2 main protease, one of two cysteine viral proteases essential for viral replication. Our crystallographic screen identified 71 hits that span the entire active site, as well as 3 hits at the dimer interface. These structures reveal routes to rapidly develop more potent inhibitors through merging of covalent and non-covalent fragment hits; one series of low-reactivity, tractable covalent fragments were progressed to discover improved binders. These combined hits offer unprecedented structural and reactivity information for on-going structure-based drug design against SARS-CoV-2 main protease. The SARS-CoV-2 main protease is an important target for the development of COVID-19 therapeutics. Here, the authors combine X-ray crystallography and mass spectrometry and performed a large scale fragment screening campaign, which yielded 96 liganded structures of this essential viral protein that are of interest for further drug development efforts.
11. The University of Iowa
Join a global community of renowned artists, pioneering scientists, and faculty dedicated to student success at the University of Iowa.
Ranked among the top 5% of universities in the world. 200+ areas of study. Located in one of America’s best college towns. Come see what it means to be a Hawkeye.
12. Temple University Hospital – Main Campus
Patients receive life-saving treatments, advanced procedures and expert care at Temple University Hospital – Main Campus.
13. National Accounts - Analysis of Main Aggregates (AMA)
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United Nations Statistics Division - National Accounts - Analysis of Main Aggregates (AMA)
